Intestinal Flora and Diseases

We investigate patients’ enterobacterial balance and prescribe a course of treatment.

Human enterobacteria include only bacteria in the phyla: Firmicutes (lactobacillus, streptococci, Clostridium genus) Actinobacteria (bifidobacteria, etc.), Bacteroides (Bacteroides genus, etc.), and Proteobacteria (colon bacilli, salmonellae, vibrios, Helicobacter pylori, etc.)

If your enterobacteria are unbalanced, illness follows.

These enterobacteria form intestinal bacterial flora and coexist with people, impacting their metabolic system and immune system.
Intestinal bacterial flora is formed by probiotic bacteria and pathogenic bacteria, so unbalancing them cause various diseases.
For example, infants with few bifidobacterial that are part of actinomycete group, are reportedly susceptible to allergies such as atopic dermatitis.
Bifidobacteria acts on lymphocytes and other immunocyte to suppress abnormal immune reaction or strengthen barriers of intestinal membranes, preventing the intrusion of allergenic substances.
It is said that generally infants naturally nursed or delivered by natural childbirth have a lot of bifidobacteria.
Recently, it has been reported that if the percentage of bacteria called Bacteroides thetaiotaomicron falls, proportionally increasing bacteria in the Firmicute phylum, obesity and diabetes occur easily.
This is because thetaiotaomicron bacteria decompose food fiber into short chain fatty acids, acting to suppress the accumulation of fat and rise of blood sugar.
It is also reported that the increase of Bacteroides fragilis bacteria increases the risk of colon cancer.
It is pointed out that in the bodies of patients suffering from ulcerative colitis or other inflammatory bowel disease, Clostridium genus bacteria fall, increasing bacteria in Bacteroides and Proteobacteria phyla.
If the distribution of bacteria in a person’s intestines changes in this way for some reason, unable to maintain its homeostasis, the person becomes ill.
To prevent this, patients must first learn about their own enterobacteria, but the DNA of enterobacteria, which are said to number about 400 can be comprehensively investigated by the t-RFLP method.
This method can judge the balance of enterobacteria, permitting a treatment method decision.
We believe this is effective in treating patients with intractable irritable bowel syndrome or stubborn constipation, so if you are suffering from these, please ask about this method.
The examination costs 30,000 yen (tax excl.).
Our clinic proposes the following therapy methods according to the results of analysis of intestinal bacterial flora.

We also offer supplements that balance your intestinal environment.

We have probiotics supplied by Metagenics of the U.S.
It is an effective treatment that not only strengthens intestinal barriers, it also treats discomfort of the alimentary canal (full feeling), allergies, ordinary diarrhea, diarrhea caused by antibiotics, and irritable bowel syndrome.
We recommend it to you if conventional stomach medicines do not work for you, or if you are lactose intolerant.
And to maintains the proper position in the intestines of probiotics and balance intestinal bacterial flora, we recommend that patients also take prebiotics with inulin or other soluble food fiber as their main constituent.

Intestinal Barrier Function Strengthening Treatment

Lactoferrin increases bifidobacteria

Intestinal tract membranes prevent the intrusion of allergenic substances by the action of an immunoglobulin called IgA, so it is assumed that a lot of IgA, discourages allergies.
If you ingest a lot of probiotic bacteria, particularly bifidobacteria, the secretion of IgA is encouraged, strengthening the barrier of intestinal tract membranes.
Bifidobacteria increases the protein called lactoferrin which is a large constituent of mother’s milk, so simultaneously taking lactoferrin is effective.
Our clinic provides lactoferrin as a supplement.
The price is 7,800 yen (tax excl.) per month.

A supplement that also helps prevent diabetes and obesity

As stated above, thetaiotaomicron bacteria effectively prevent diabetes and obesity, but at this time there is no preparation that allows patients to ingest this bacteria directly.
Therefore, you have to increase your thetaiotaomicron bacteria through your diet.
It has been proven that bacteria is increased by the action of polyphenols that are in food fiber that is a constituent of burdock root etc., polyphenol in blueberries etc., and the action of beta-glucan oligosaccharide in wheat.
If it is difficult for you to ingest these nutrients in your food, we will show you a supplement.

Colon cancer prevention bacteria eradication therapy

This is based on information that Bacteroides fragilis bacteria can cause colon cancer published in the science magazine Nature.
Antibiotics that eradicate this bacteria are also used to eradicate Helicobacter pylori, so their safety is guaranteed.
After eradication, it is important that probiotic bacteria increase, preventing the return of the fragilis bacteria.

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